abstract：:The fundamental tasks of the root system are, besides anchoring, mediating interactions between plant and soil and providing the plant with water and nutrients. The architecture of the root system is controlled by endogenous mechanisms that constantly integrate environmental signals, such as availability of nutrients ...

journal_title：Current opinion in genetics & development

authors： Ötvös K,Benková E

更新日期：2017-08-01 00:00:00

abstract：:To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue def...

journal_title：Current opinion in genetics & development

authors： Suzuki T,Morishita Y

更新日期：2017-08-01 00:00:00

abstract：:Several decades of research provided detailed insight into how genes control development and evolution, whereas recent studies have expanded this purely genetic perspective by presenting strong evidence for environmental and epigenetic influences. We summarize examples of phenotypic plasticity and trans-generational e...

journal_title：Current opinion in genetics & development

authors： Serobyan V,Sommer RJ

更新日期：2017-08-01 00:00:00

abstract：:Peripheral neuropathies are characterized by degeneration of peripheral motor, sensory and/or autonomic axons, leading to progressive distal muscle weakness, sensory deficits and/or autonomic dysfunction. Acquired peripheral neuropathies, e.g., as a side effect of chemotherapy, are distinguished from inherited periphe...

journal_title：Current opinion in genetics & development

authors： Bussmann J,Storkebaum E

更新日期：2017-06-01 00:00:00

abstract：:More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3-6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-function. The expanded RNA...

journal_title：Current opinion in genetics & development

authors： Zhang N,Ashizawa T

更新日期：2017-06-01 00:00:00

abstract：:Differential gene expression gives rise to the many cell types of complex organisms. Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit cofactors to activate RNA Polymerase II at core promoters. Transcriptional regulation is typically mediated by distinct combinations of TFs...

journal_title：Current opinion in genetics & development

authors： Reiter F,Wienerroither S,Stark A

更新日期：2017-04-01 00:00:00

abstract：:The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approa...

journal_title：Current opinion in genetics & development

authors： Tsoucas D,Yuan GC

更新日期：2017-02-01 00:00:00

abstract：:Genomic information from ancient human remains is beginning to show its full potential for learning about human prehistory. We review the last few years' dramatic finds about European prehistory based on genomic data from humans that lived many millennia ago and relate it to modern-day patterns of genomic variation. T...

journal_title：Current opinion in genetics & development

authors： Günther T,Jakobsson M

更新日期：2016-12-01 00:00:00

abstract：:Empowered by modern genotyping and large samples, population structure can be accurately described and quantified even when it only explains a fraction of a percent of total genetic variance. This is especially relevant and interesting for humans, where fine-scale population structure can both confound disease-mapping...

journal_title：Current opinion in genetics & development

authors： Novembre J,Peter BM

更新日期：2016-12-01 00:00:00

abstract：:We discuss recent work about cellular reprogramming during regeneration of the imaginal discs of Drosophila. These contain various lineage blocks, compartments, which express distinct genetic programmes. It has been found that after massive damage to a compartment cells from a neighbour compartment can transgress the ...

journal_title：Current opinion in genetics & development

authors： Morata G,Herrera SC

更新日期：2016-10-01 00:00:00

abstract：:Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this regenerative response are Müller glia that respond to retinal injury by undergoing a reprogramming event that allows them to divide and generate a retinal progenitor that is multipotent and responsible for regenerating all major retinal neu...

journal_title：Current opinion in genetics & development

authors： Wan J,Goldman D

更新日期：2016-10-01 00:00:00

abstract：:The impressive diversity of body plans, lifestyles and segmental specializations exhibited by crustaceans (barnacles, copepods, shrimps, crabs, lobsters and their kin) provides great material to address longstanding questions in evolutionary developmental biology. Recent advances in forward and reverse genetics and in...

journal_title：Current opinion in genetics & development

authors： Stamataki E,Pavlopoulos A

更新日期：2016-08-01 00:00:00

abstract：:Colonial ascidians are marine invertebrate chordates that are the closest invertebrate relative to the vertebrates. Colonies of Botryllus schlosseri undergo a continuous asexual reproduction process that involves the regeneration of entire new bodies, which include all somatic and germline tissues. This adult regenera...

journal_title：Current opinion in genetics & development

authors： Kassmer SH,Rodriguez D,De Tomaso AW

更新日期：2016-08-01 00:00:00

abstract：:Trait exaggeration, well known to naturalists and evolutionary biologists, has recently become a prominent research subject in the modern field of Evolutionary Developmental Biology. A large number of traits that can be considered as cases of exaggeration exist in nature. Yet, the field has almost exclusively focused ...

journal_title：Current opinion in genetics & development

authors： Toubiana W,Khila A

更新日期：2016-08-01 00:00:00

abstract：:Current dogma holds that genes are the property of individual mammalian cells and partition between daughter cells during cell division. However, and rather unexpectedly, recent research has demonstrated horizontal cell-to-cell transfer of mitochondria and mitochondrial DNA in several mammalian cell culture systems. F...

journal_title：Current opinion in genetics & development

authors： Berridge MV,McConnell MJ,Grasso C,Bajzikova M,Kovarova J,Neuzil J

更新日期：2016-06-01 00:00:00

abstract：:Mitochondria are highly abundant in and essential to the beat-to-beat contractile performance of hearts. However, relatively few cardiac diseases have been attributed to primary mitochondrial dysfunction. The paucity of evidence for 'primary mitochondrial cardiac diseases' may be because such an entity does not exist....

journal_title：Current opinion in genetics & development

authors： Dorn G II

更新日期：2016-06-01 00:00:00

abstract：:Recent technological and computational advances in understanding the transcriptional and chromatin features of single cells have begun answering longstanding questions in the extent and impact of biological heterogeneity. Here, we outline the intrinsic and extrinsic mechanisms that underlie the transcriptional and fun...

journal_title：Current opinion in genetics & development

authors： Martinez-Jimenez CP,Odom DT

更新日期：2016-04-01 00:00:00

abstract：:Retrotransposons are mutagenic units able to move within the genome. Despite many defenses deployed by the host to suppress potentially harmful activities of retrotransposons, these genetic units have found ways to meld with normal cellular functions through processes of exaptation and domestication. The same host mec...

journal_title：Current opinion in genetics & development

authors： Mita P,Boeke JD

更新日期：2016-04-01 00:00:00

abstract：:Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene expression because they directly govern the degree of DN...

journal_title：Current opinion in genetics & development

authors： Maeshima K,Ide S,Hibino K,Sasai M

更新日期：2016-04-01 00:00:00

abstract：:Proteins, the main cell machinery which play a major role in nearly every cellular process, have always been a central focus in biology. We live in the post-genomic era, and inferring information from massive data sets is a steadily growing universal challenge. The increasing availability of fully sequenced genomes ca...

journal_title：Current opinion in genetics & development

authors： Scaiewicz A,Levitt M

更新日期：2015-12-01 00:00:00

abstract：:Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryoge...

journal_title：Current opinion in genetics & development

authors： Leung CY,Zernicka-Goetz M

更新日期：2015-10-01 00:00:00

abstract：:Microfluidic devices employ submillimeter length scale control of flow to achieve high-resolution spatial and temporal control over the microenvironment, providing powerful tools to elucidate mechanisms of human pluripotent stem cell (hPSC) regulation and to elicit desired hPSC fates. In addition, microfluidics allow ...

journal_title：Current opinion in genetics & development

authors： Qian T,Shusta EV,Palecek SP

更新日期：2015-10-01 00:00:00

abstract：:Life-long neurogenesis is highly restricted to specialized niches in the adult mammalian brain and therefore the brain's capacity for spontaneous regeneration is extremely limited. However, recent work has demonstrated that under certain circumstances parenchymal astrocytes and NG2 glia can generate neuronal progeny. ...

journal_title：Current opinion in genetics & development

authors： Péron S,Berninger B

更新日期：2015-10-01 00:00:00

abstract：:In recent years, studies of cis-regulatory mechanisms have evolved from a predominant focus on promoter regions to the realization that spatial and temporal gene regulation is frequently driven by long-range enhancer clusters that operate within chromosomal compartments. This increased understanding of genome function...

journal_title：Current opinion in genetics & development

authors： Miguel-Escalada I,Pasquali L,Ferrer J

更新日期：2015-08-01 00:00:00

abstract：:Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and tr...

journal_title：Current opinion in genetics & development

authors： Sanders SJ

更新日期：2015-08-01 00:00:00

abstract：:Vertebrate eye formation is a multistep process requiring coordinated inductive interactions between neural and non-neural ectoderm and underlying mesendoderm. The induction and shaping of the eyes involves an elaborate cellular choreography characterized by precise changes in cell shape coupled with complex cellular ...

journal_title：Current opinion in genetics & development

authors： Bazin-Lopez N,Valdivia LE,Wilson SW,Gestri G

更新日期：2015-06-01 00:00:00

abstract：:The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, d...

journal_title：Current opinion in genetics & development

authors： Whitfield TT

更新日期：2015-06-01 00:00:00

abstract：:The Caenorhabditis elegans hermaphrodite vulva is one of the best studied models for signal transduction and cell fate determination during organogenesis. Systematic forward genetic screens have identified a complex and highly interconnected signaling network formed by the conserved EGFR, NOTCH, and WNT signaling path...

journal_title：Current opinion in genetics & development

authors： Schmid T,Hajnal A

更新日期：2015-06-01 00:00:00

abstract：:Flowers are central to sexual reproduction in plants. The study of floral development proved tremendously successful in obtaining key insight into processes, such as fate determination, pattern formation, and growth regulation. Recent advances relate to the complex mechanisms underlying the crosstalk between phytohorm...

journal_title：Current opinion in genetics & development

authors： Vaddepalli P,Scholz S,Schneitz K

更新日期：2015-06-01 00:00:00

abstract：:As immunotherapies to treat malignancy continue to diversify along with the tumor types amenable to treatment, it will become very important to predict which treatment is most likely to benefit a given patient. Tumor neoantigens, novel peptides resulting from somatic tumor mutations and recognized by the immune system...

journal_title：Current opinion in genetics & development

authors： Snyder A,Chan TA

更新日期：2015-02-01 00:00:00

abstract：:The genotype-phenotype map of human evolution is difficult to access since humans cannot be crossed with other species. Most of the ∼20 million genetic changes that occurred since the human and the chimpanzee lineage split, are fixed and hence completely correlated with all phenotypic changes that occurred during huma...

journal_title：Current opinion in genetics & development

authors： Enard W

更新日期：2014-12-01 00:00:00

abstract：:The generation of induced pluripotent stem cells (iPSCs) with Oct4, Sox2, Klf4, c-Myc has been described as 'direct' reprogramming in contrast to reprogramming via nuclear transfer. Interestingly, recent studies have suggested that the conversion process itself includes transient up-regulation and down-regulation of h...

journal_title：Current opinion in genetics & development

authors： Ruetz T,Kaji K

更新日期：2014-10-01 00:00:00

abstract：:Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medici...

journal_title：Current opinion in genetics & development

authors： Yu C,Liu K,Tang S,Ding S

更新日期：2014-10-01 00:00:00

abstract：:Pluripotency-associated transcription factors possess a pivotal role to maintain pluripotency in pluripotent stem cells as well as to induce pluripotency in somatic cells. They direct specific pattern of gene expression from the genome by co-operating with the genetic and epigenetic mechanisms. Recent findings reveale...

journal_title：Current opinion in genetics & development

authors： Niwa H

更新日期：2014-10-01 00:00:00

abstract：:The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at tel...

journal_title：Current opinion in genetics & development

authors： Rossiello F,Herbig U,Longhese MP,Fumagalli M,d'Adda di Fagagna F

更新日期：2014-06-01 00:00:00

abstract：:Over the past twenty years, exciting developments in optical and molecular imaging approaches have allowed researchers to examine with unprecedented resolution the spatial organization of transcription sites in the nucleus. An attractive model that has developed from these studies is that active genes cluster to prefo...

journal_title：Current opinion in genetics & development

authors： Buckley MS,Lis JT

更新日期：2014-04-01 00:00:00

abstract：:The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and ove...

journal_title：Current opinion in genetics & development

authors： Luperchio TR,Wong X,Reddy KL

更新日期：2014-04-01 00:00:00

abstract：:Over the last decade we have witnessed the convergence of two powerful experimental designs toward a common goal of defining the molecular subtypes that underpin the likelihood of a cancer patient responding to treatment in the clinic. The first of these 'experiments' has been the systematic sequencing of large number...

journal_title：Current opinion in genetics & development

authors： Garnett MJ,McDermott U

更新日期：2014-02-01 00:00:00

abstract：:Genome instability is a feature of nearly all cancers and can be exploited for therapy. In addition, a growing number of genome maintenance genes have been associated with developmental disorders. Efforts to understand the role of genome instability in these processes will be greatly facilitated by a more comprehensiv...

journal_title：Current opinion in genetics & development

authors： Balmus G,McIntyre RE

更新日期：2014-02-01 00:00:00

abstract：:Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While it has long been appreciated that topographic complexities on fitness landscapes can arise only as a consequence of epistatic interactions between mutations, e...

journal_title：Current opinion in genetics & development

authors： Weinreich DM,Lan Y,Wylie CS,Heckendorn RB

更新日期：2013-12-01 00:00:00